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For More Information, Contact:

Brian P. Callahan, Chief Financial Officer
(615) 261-1500
bcallahan@spheris.com

Lisa DeMoss
Director, Marketing and Communications
(615) 261-1716
ldemoss@spheris.com

For Immediate Release

Spheris Sets First Quarter 2008 Earnings Release And Conference Call Dates

FRANKLIN, Tenn. — April 21, 2008 — Spheris, a leading global provider of clinical documentation technology and services, today announced details for the release of its financial results for the first quarter ended March 31, 2008.

Spheris plans to issue its earnings release for the first quarter of 2008 after the close of market trading on Monday, May 12, 2008, and will host a conference call on Tuesday, May 13, 2008, at 8 a.m. CT. The number to call for this interactive teleconference is (303) 262-2139. Following the conference call, the audio replay will be available for one week by dialing (303) 590-3000 and entering the confirmation number, 11111009#.

The live broadcast of Spheris' quarterly conference call will be available online at www.spheris.com and http://www.videonewswire.com/event.asp?id=47602 on May 13, 2008, at 8 a.m. CT. The online replay will be available shortly after the call and will continue for 30 days.

About Spheris Spheris is a leading provider of clinical documentation services and technology to health systems, hospitals and group practices throughout the U.S. Founded by physicians in 1993, Spheris employs a global network of medical language specialists for true 24-hour service, seven days a week, 365 days a year. The proprietary Spheris Clarity™ technology platform integrates the full range of clinical documentation software and hardware into one seamless, customizable system, including embedded speech recognition technologies. The Spheris solution is flexible and scalable to balance the needs of HIM directors, CFOs, IT directors and physicians with an emphasis on verifiable quality, turnaround time, security and pricing. Spheris' worldwide corporate headquarters is located in Franklin, Tenn. For more information, please visit www.spheris.com.